01 - Preheat grill or large skillet to medium-high heat, approximately 375-400°F.
02 - Combine ground beef, kosher salt, black pepper, garlic powder, and onion powder in mixing bowl. Mix gently just until incorporated, avoiding overworking the meat.
03 - Divide seasoned beef into 12 equal portions. Shape into patties slightly wider than slider buns, creating a small indentation in center to prevent puffing during cooking.
04 - Place patties on preheated grill or skillet. Cook for 2-3 minutes per side until well-browned and internal temperature reaches 160°F for medium doneness.
05 - During final minute of cooking, place one cheese slice on each patty. Cover with lid or dome to trap heat and melt cheese completely.
06 - Slice slider buns horizontally. Brush cut sides with melted butter and toast on grill or skillet until golden brown and crispy, approximately 1-2 minutes.
07 - Spread ketchup, mustard, and mayonnaise on bottom buns. Place cheesy patties on dressed buns. Top with sliced pickles and red onion. Crown with top buns and sprinkle with sesame seeds if using.
08 - Arrange sliders on platter and serve hot while cheese remains melted. Pair with cold beverages for optimal tailgate experience.